Spectral Studies of Analgesic, Antipyretic and Anti-Inflammatory Drugs Used in Medical Therapy in Romania
University of Medicine and Pharmacy Carol Davila Bucharest, University of Medicine and Pharmacy , Bucharest
Human health decline is most commonly manifested by pain and sometimes fever in the initial phase of the disease. Analgesics, antipyretics and anti-inflammatories serve as drugs with various chemical structures which showcase in different proportions their main actions. They represent medicines that suppress pain and fight fever.
The aim of the study is studying the usual types of therapeutic indications using modern spectral analysis, based on the analgesic, antipyretic and anti-inflammatory actions used in Romania. For each of these indications, the substances may be used either alone, in isolation or in combination, in complex formulations. The following spectral analysis methods are used to control the chemical compositions of the studied drugs: UV-VIS analyses and IR analyses. In the UV-VIS analysis spectra, a molecule absorption spectrum is obtained and the Lambert-Beer law is used to obtain quantitative data. IR spectrophotometry is mainly used to identify drug substances without destroying the molecules integrity. IR absorption is characteristic of a wide range of functional groups, bonds, and structural units. Analyzed drugs by UV-VIS and IR techniques are: aspirin, paracetamol, nimesulide and sodium diclofenac. Our study can contribute to a spectrum atlas that can be used in drug control.
Keywords: UV-VIS spectra, IR spectra, analgesic, antipyretic, anti-inflammatory.